Andy Morrison / toledoblade.com

A fire destroyed a single-family home in Seneca County, Ohio, on Tuesday.

Two adults and three children died Tuesday morning in a fire that destroyed a two-story farmhouse in northern Ohio, authorities said.

A truck driver traveling along State Route 162 reported the blaze in Reed Township at 3:17 a.m., said Dean Henry, public information officer for Seneca County.

When firefighters arrived, the single-family home was "fully involved," Henry said.

After extinguishing the blaze, firefighters went inside and found the bodies of two adults and three children – a 12-year-old girl and two boys ages 6 and 8, Henry said. The adults were believed to be the children’s parents.

The cause of the blaze wasn't immediately known. The state fire marshal was investigating.

No one else was in the home at the time and no firefighters were hurt, Henry said.

Firefighters from five departments -- Attica, Republic, Huron River, Monroeville and Bellevue -- responded to the blaze, according to The Toledo Blade.

More content from NBCNews.com:

• South Korea to sack Tampa socialite Jill Kelley as honorary consul
• Four men sue NJ 'gay conversion' group over promises to make them straight
• Search for missing Colorado boy suspended as lake sweep yields no clues
• Woman denies murder to avenge husband's death
• Columbine survivor turns to Occupy LA to battle foreclosure
• Video: Should children use medical marijuana?

Follow US news from NBCNews.com on Twitter and Facebook